|Name||immunodeficiency with hyper IgM type 3|
|Definition||A hyper IgM syndrome that has_material_basis_in mutation in the TNFRSF5 gene, resulting in type 3 hyper-IgM immunodeficiency that is characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
CD40 deficiency [EXACT]
hyper-IgM syndrome due to CD40 deficiency [EXACT]
type 3 hyper-IgM immunodeficiency [EXACT]
is_a hyper IgM syndrome